Towards a pro-active manifesto aims to share the connected approaches in research and practice to develop professional and ethical competences in relation to local urban development practices in strongly globalized contexts. This Manifesto is based on two workshops held in 2014 in Genoa and Hannover and supplemented by a thematical framework provided in research of the Università degli Studi di Genova (DSA Department) and the Leibniz Universität Hannover (Department of Urban Design and Planning). This international collaboration has been supported by the programme Hochschuldialog with Südeuropa of DAAD, the German Academic Exchange Service.