The stark contrast of the desert, mountains, seas, and cataracts surrounding the fertile river valley creates a dramatic separation between Egypt and the rest of the world. Despite this physical – often pretended – barrier, Egypt has historically been deeply connected to the cultures of the Eastern Mediterranean, Western Asia, and Northeast Africa. These interactions have led to a complex intermingling of culture, materials, religions, ideas, and iconography, resulting in the emergence of new forms of cultural identity. The papers of this volume, presented to prof. Marilina Betrò, aim to explore various aspects of these interactions, spanning from the 3rd millennium BC to Roman and Medieval times, encompassing regions from Mesopotamia to the Levant, from Anatolia to the Aegean, and from the Roman Empire to Syria.